RNA tectonics refers to the construction of beautiful and useful artificial RNA supra-molecular architectures and takes advantage of the knowledge of folding rules and assembly rules governing the three-dimensional shape of complex natural RNA molecules (1). We have recently demonstrated our ability to generate tectoRNAs, self-assembling RNA building blocks that are designed and programmed to generate RNA super-architectures in a highly predictable manner (2,3). In other words, tectoRNAs can be perceived as "smart" LEGO pieces that can find their way to assemble into a final supra-molecular object. For instance, by using a combination of theoretical and experimental approaches, we can predict, design and control the self-assembly of tectoRNAs into directional nano-fibers with different supra-molecular topologies and geometries (4,5). TectoRNAs that self-assemble into precise geometrical figures are presently used to generate cellular automata (5). Our latest results that aim at using these automata to design programmable self-assembling RNA arrays will be presented. RNA tectonics opens the way to the creation of novel scaffoldings for the generation of "smart" biomaterials. It can also be used as a powerful mean to decipher the logic of RNA assembly.
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 Baudrey, S., Nasalean, L. Leontis, N.B. & Jaeger, L. (2003) In preparation.
 Chworos, A., Oroudjev, E., Weinkam, P., Hansma, H. & Jaeger, L. (2003) In preparation.