February 2016

Gaming the Future: The Book!

DNA nanotechnology provides new ways to arrange nanoparticles into crystal lattices

Two research teams present two different methods for using single strands of DNA to link various nanoparticles into complex 3D arrays: one using DNA hairpins for dynamic reconfiguration and the other using a DNA origami scaffold.

Improving crystallographic resolution through using less perfect crystals

A paradigm shift in analyzing diffraction from smaller, less perfect crystals yields improved resolution and enables directly determining the phase of the diffraction pattern.

DNA nanotechnology cages localize and optimize enzymatic reactions

Encapsulating enzymes in nanocages engineered using structural DNA nanotechnology increases enzymatic digestion and protects enzymes from degradation.

Roles of materials research and polymer chemistry in developing nanotechnology

Polymer chemistry and materials research provide opportunities to explore structures that harmonize phenomena unique to nanoscale technology, the role of mechanical forces generated at interfaces, and the responses of biological systems to mechanical stresses.

Multiple advances in de novo protein design and prediction

New families of protein structures, barrel proteins for positioning small molecules, self-assembling protein arrays, and precision sculpting of protein architectures highlight de novo protein design advances.

Rational design of protein architectures not found in nature

Computational design of proteins satisfying predetermined geometric constraints produced stable proteins with the designed structure that are not found in nature.

De novo protein design space extends far beyond biology

A fully automated design protocol generates dozens of designs for proteins based on helix-loop-helix-loop repeat units that are very stable, have crystal structures that match the design, have very different overall shapes, and are unrelated to any natural protein.

Gaming the Future: The Book!

Month: February 2016

DNA nanotechnology provides new ways to arrange nanoparticles into crystal lattices

Improving crystallographic resolution through using less perfect crystals

DNA nanotechnology cages localize and optimize enzymatic reactions

Roles of materials research and polymer chemistry in developing nanotechnology

Multiple advances in de novo protein design and prediction

Rational design of protein architectures not found in nature

De novo protein design space extends far beyond biology

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