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Triple helices stabilize macroscopic crystals for DNA nanotechnology

A DNA strand capable of forming a triple helix with a portion of the DNA double helices in a macroscopic DNA crystal enhances the weak interactions holding the crystal together so that the crystal remains stable in the absence of a high ionic strength environment.

DNA nanotechnology defeats drug resistance in cancer cells

Small, stiff, rectangular rods made using scaffolded DNA origami bypass drug resistance mechanisms in the membranes of a cultured leukemia cell line and release enough therapeutic drug to kill the cancer cell.

DNA nanotechnology provides new ways to arrange nanoparticles into crystal lattices

Two research teams present two different methods for using single strands of DNA to link various nanoparticles into complex 3D arrays: one using DNA hairpins for dynamic reconfiguration and the other using a DNA origami scaffold.

DNA nanotechnology cages localize and optimize enzymatic reactions

Encapsulating enzymes in nanocages engineered using structural DNA nanotechnology increases enzymatic digestion and protects enzymes from degradation.

DNA nanotechnology controls which molecules enter cells

DNA building blocks mimic biological ion channels to more precisely control which molecules can cross a biological membrane.

Using DNA nanotechnology to position molecules with atomic precision

German researchers have used scaffolded DNA origami to adjust the angle of a DNA hinge joint by altering the length of special “adjuster helices”, causing molecules attached to the sides of the hinge to be displaced by as little as 0.04 nm.

DNA nanotechnology guides assembling cells into ‘Organoids’

DNA strands decorating cell membranes like ‘Velcro’ program the adhesion of cells to other cells or to extracellular matrices to build tiny tissue models.

Facilitating structural DNA nanotechnology with non-aqueous solvents

Recent research demonstrates that certain non-aqueous solvents can not only be used to assemble DNA nanostructures, but offer certain advantages over conventional aqueous solvents.

Dynamic nanomachines for DNA nanotechnology inspired by proteins

Programmed assembly and disassembly of rigid 3D DNA origami objects has been achieved by designing complementary surface shapes based upon weak stacking interactions to create simple nanomachines.

Designing mechanical functions into DNA nanotechnology

An overview of three decades of progress in DNA nanotechnology emphasizes bringing programmed motion to DNA nanostructures, including efforts to incorporate design principles from macroscopic mechanical engineering.

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