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Novel nanoparticle efficiently silences gene expression in liver cells

RNA interference provides potential cures for various diseases by silencing the expression of specific genes in specific organs, but delivering the RNA molecules to the right place is very difficult. A novel nanoparticle provides unprecedented efficiency in silencing target genes in liver cells.

Atomically precise nanoparticle provides better drug delivery

Nanoparticles made from specific DNA and RNA strands, homogeneous in size, composition, and surface chemistry, proved superior to other nanoparticles in silencing gene expression in tumors in mouse experiments.

'Good Cholesterol' nanoparticles silence cancer-promoting genes and destroy cancer cells

‘Good Cholesterol’ nanoparticles are non-toxic and use the need of cancer cells for HDL cholesterol to deliver RNA molecules to silence the expression of cancer-promoting genes.

Surface properties of nanoparticles have profound effect on how cells respond

Gold nanoparticles carrying nucleic acids into a cell must have the nucleic acids tightly linked via covalent bonds to avoid profound, unanticipated effects on gene expression.

Nanotechnology approach to drug delivery uses multifunctional nanoparticles to silence gene

A major nanotech advance in engineering multifunctional nanoparticles for imaging and therapeutic applications combines a short RNA (siRNA) to “silence” a specific gene with quantum dots and a “proton sponge” polymer coating to get the siRNA into the cell and released into the right compartment of the cell.

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