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Coating micrometer-sized glass spheres with hundreds of DNA strands complementary to an RNA covering a glass slide enables the sphere to move, with the help of an enzyme that digests RNA bound to complementary DNA, a thousand times faster than conventional DNA-walkers.
Scientists have succeeded in coordinating the movements of the biped’s legs so that it can walk in one direction along a DNA track without the need of intervention at each step.
DNA nanotech continues to improve the devices it produces as Oxford University scientists fix several shortcomings seen in earlier versions of bipedal DNA molecular walkers.
Aharia Nair brings to our attention the new term Nubot, for Nucleic Acid Robots. Wikipedia explains: Nubot is an abbreviation for “Nucleic Acid Robots.” Nubots are synthetic robotics devices at the nanoscale. Representative nubots include the several DNA walkers reported by Ned Seeman’s group at NYU, Niles Pierce’s group at Caltech, John Reif’s group at… Continue reading Meet the Nubot: DNA nanotechnology robots
Roland Piquepaille writes "Two chemists from New York University, William B. Sherman and Nadrian C. Seeman, have created a DNA nanowalker with two legs, each one being 10-nanometers long. This nanoscale bipedal robot moves from one pair of anchors — strands of DNA — to another one. This is a major breakthrough for nanoscale manufacturing. And New Scientist says this opens the way for future nanoscopic robots that will assemble other nanomachines or manipulate individual molecules. Obviously, this is still at the experimental stage. Even the researchers don't say when such nanowalkers will be able to do some real work. More details are available in this overview."
A review of molecular parts that act as switches, motors, and ratchets illuminates similarities between artificial and biological molecular machines and argues that useful applications are coming.
Swiss researchers have used biomolecular shuttles to capture molecular building blocks from solution and transport them across fluid flow boundaries to be further manipulated in a subsequent chamber.
Summary David Baker from the University of Washington presents breakthrough advancements in de novo protein design. Deep learning pattern recognition hallucinates the desired protein structure and also generates the correct peptide sequence for accurate folding, and predicted proteins are highly transferable to actual proteins produced in a lab. Results are easily transferable to the production… Continue reading Protein-based Assemblies and Molecular Machines | David Baker, University of Washington
Among the smallest molecular robots reported so far, a walker based on phenylarsonous acid with two organic thiol ligands as feet walks through a one-nanometer-diameter protein nanopore channel by taking 0.6 nanometer steps, by thiol exchange, from one cysteine residue to the next.
News articles by Jon Cartwright on the Chemistry World news site and by Michael Berger at Nanowerk describe a significant molecular machine milestone achieved by the research groups of David A. Leigh (winner of the 2007 Foresight Institute Feynman Prize in Nanotechnology for Theory) and Anne-Sophie Duwez. The research was reported in Nature Nanotechnology [abstract].… Continue reading First direct measurement of force generated by an individual synthetic molecular machine