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Solid state synthetic molecular machine points to advanced nanotechnology

Interlocking organic molecules held between copper atoms have been assembled in a void inside a solid state material to create a very simple molecular machine, a wheel that spins around an axle.

An expanded genetic alphabet could lead to more easily designed proteins

The demonstration that the process of DNA replication is more flexible than thought should make it easier to incorporate unusual amino acids into designed proteins, which might make it easier to design novel protein machines.

New Darpa program may accelerate synthetic biology path to advanced nanotechnology

Darpa has launched a “Living Foundries” program to bring an engineering perspective to synthetic biology to greatly accelerate progress through standardization and modularization.

Foresight Institute on Singularity Hub (video)

Recent interview touches on new Foresight programs and issues in nanotechnology development

Machine learning may improve molecular design for nanotechnology

A set of machine learning programs can now predict properties of small organic molecules as accurately as can calculations based upon the Schrödinger equation, but in milliseconds rather than hours.

Crowd-sourced protein design a promising path to advanced nanotechnology

Foldit game players have again out-performed scientists in protein design, this time improving the design of a protein designed from scratch to catalyze Diels-Alder cycloadditions.

Advanced nanofactories in twenty years?

An article in The Guardian quotes Christine Peterson and Robert Freitas on the vision of molecular manufacturing. Freitas is quoted as expecting that the development of nanofactories could be done in 20 years for “on the order of” one billion dollars.

Artificial molecular motor controls molecular transformation

A four-step unidirectional molecular motor driven by light and temperature changes catalyzes different chemical reactions at different steps of its rotary cycle.

An artificial molecular clock to control artificial molecular machines

The oscillating synthesis and degradation of regulatory RNA molecules was used to produce a molecular clock to control the opening and closing of a DNA tweezers, and also to control the production of another RNA molecule to alter the fluorescence of a dye molecule.

Destroying cancer cells by incorporating an artificial biological computer

A complex piece of DNA that acts as a biological computer when it is inserted into cells determines whether or not the cell is a specific type of cancer cell, and if so, initiates the suicide of that cell.

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