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from the unnatural-selection dept.
vik points out an item about researchers at the Massachusetts General Hospital in Boston who have been developing proteins with specific binding affinity by pseudo-evolutionary processes, which appeared on Natureís Science Update site. Researchers Anthony Keefe and Jack Szostak have developed a method to indetify proteins to do a predetermined job from a vast number of random genes. The article makes an explicit connection to the potential of protein design as a pathway toward nanotechnology:
"It's 20 years since Eric Drexler, one of the prophets of nanotechnology, suggested that proteins could be engineered, and that molecular machines could be used in computing or medicine. But protein design has proved damnably difficult, because of our inability to predict how a linear sequence of amino acids will fold up into a three-dimensional protein. An evolutionary approach might sidestep this problem."
Drexler's 1981 paper in the Proceedings of the National Academy of Sciences USA, which first proposed the protein engineering pathway, is cited.
vik writes: "An evolutionary approach to protein design may be more fruitful than protein-folding predictions in producing either protein-based machinery or using custom proteins as templates for the catalysis of nanoscale components."
World Business Forum – FUTURACT 2000, 19th & 20th December 2000, Paris, France. “Futuract highlights main trends – economic, technological, sociological and political – which may influence the very foundation of future economics, deals with the way exchanges operate and are regulated, as well as the way in which new technologies are involved in current… Continue reading Events Library 1999–2000
General Program Conference Proceedings Update articles about the Conference The first in the series of Foresight Conferences on Molecular Nanotechnology. The conference was held October 27-29, 1989. This was the first comprehensive conference on the topic of nanotechology. The conference drew participants from three continents and many disciplines. Conference Location Stanford UniversityPalo Alto, CA… Continue reading The First Foresight Conference on Nanotechnology
page 2 A publication of the Foresight Institute Foresight Update 17 – Table Of Contents I Page1 I Page2 I Page3 I Page4 I Page5 Recent Progress: Steps Toward Nanotechnology by Russell Mills Protein design metal binding sites in a de novo designed protein An advance in understanding the folding and stability of proteins… Continue reading Foresight Update 17
Vision Weekend is Now Live!! Our Vision Weekends are the annual member festivals of Foresight Institute. Held in two countries, over two weekends, top talent across biotechnology, nanotechnology, neurotechnology, computing, and space are encouraged to burst their tech silos, and plan for flourishing long-term futures together. Get your early-bird tickets for Vision Weekend France or Vision… Continue reading Prizes, Salons, and Fellowship: Foresight March 2023 Newsletter
Presenter Basile Wicky, Baker Lab Basile Wicky is currently a postdoc at the Institute for Protein Design (UW) in the group of David Baker where he works on developing deep learning methods for designing protein assemblies. He received his PhD under the supervision of Jane Clarke (University of Cambridge) where he applied experimental biophysical techniques… Continue reading Basile Wicky | Designing De Novo Interactomes for Biomolecular Computations
Workshop Molecular Systems Design Hosted by September 11 – 12, 2023, 9 am – 5 pm Hosted by Adam Marblestone Convergent Research Benjamin Reinhardt Speculative Technologies Allison Duettmann Foresight Institute The Institute, Salesforce Tower, San Francisco Apply for a Subsidized Ticket Buy Tickets NOW ! Apply to join Become a Sponsor Goal Complex molecular machines… Continue reading Foresight Molecular Systems Design Workshop 2023
Presenter Alexis Courbet, researcher at University of Washington The conversion of chemical energy into mechanical work can be regarded as the most technologically transformative advances of modern science. Yet, even decades after Feynman’s insights on molecular machines, the capability to perform useful work remains limited to the macroscale. The realization that natural molecular motors generate… Continue reading Alexis Courbet, researcher at University of Washington | Computational Design of Genetically Encodable Nanomachines
Jacob Swett, Blueprint Biosecurity Technology Development. Biosecurity. Novel Sequencing Technologies. Nanoscale Biosensing. Bioelectronics. Infectious Disease Diagnostics. Next-Generation Nanopore Biosensors. Nanofabrication. Technology for Biodefense. Pathogen Biosurveillance. Technology Policy. Atomically Precise Fabrication. Summary: Jacob Swett, previously a scientist at Arizona State University, claims that the top-down and bottom-up processes of nanofabrication and protein design can ‘meet in… Continue reading Jacob Swett, Blueprint Biosecurity | There’s Plenty of Room in the Middle
Presenter Adam Marblestone, CEO of Convergent Research I am the CEO of Convergent Research. We’ve been launching Focused Research Organizations (FROs) such as E11 bio and Cultivarium. I also serve on the boards of several non-profits pursuing new methods of funding and organizing scientific research including Norn Group and New Science. Previously, I was a… Continue reading Adam Marblestone, CEO of Convergent Research | Design Tools
