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Presenter Adam Marblestone, CEO of Convergent Research I am the CEO of Convergent Research. We’ve been launching Focused Research Organizations (FROs) such as E11 bio and Cultivarium. I also serve on the boards of several non-profits pursuing new methods of funding and organizing scientific research including Norn Group and New Science. Previously, I was a… Continue reading Adam Marblestone, CEO of Convergent Research | Design Tools
Presenter Alexis Courbet Alexis Courbet, PhD., PharmD., is an HHMI research associate at the institute for protein design (IPD), at the University of Washington’s School of Medicine. Dr. Courbet joined the IPD in 2016 to investigate computational approaches…. Alexis’s research proposes to investigate computational design rules to rationally install biochemical energy driven dynamic and mechanical… Continue reading Alexis Courbet | Towards Computational Design of Self Assembling &Genetically Encodable Nanomachines
Summary David Baker from the University of Washington presents breakthrough advancements in de novo protein design. Deep learning pattern recognition hallucinates the desired protein structure and also generates the correct peptide sequence for accurate folding, and predicted proteins are highly transferable to actual proteins produced in a lab. Results are easily transferable to the production… Continue reading Protein-based Assemblies and Molecular Machines | David Baker, University of Washington
Protein design has been one of the major paths from current fabrication technology toward the goal of general purpose, high-throughput atomically precise manufacturing since Foresight co-founder Eric Drexler proposed it in 1981. It also produced some of the earliest promising results. Although de novo protein design was at first slow, progress has accelerated since David… Continue reading Design of hyperstable constrained peptides
Ten designs spanning three types of icosahedral architectures produce atomically precise multi-megadalton protein cages to deliver biological cargo or serve as scaffolds for organizing various molecular functions.
A trimeric protein was designed to self assemble into a 60 unit icosahedron with a roomy interior that might find use to ferry molecular cargo into cells or as a chemical reactor.
Chains of monomers joined by non-biological peptoid bonds follow different rules of self-assembly and form structures not found in chains joined by the peptide bonds used to form proteins.
An engineered protein controls the assembly of C60 fullerene molecules into an atomically precise lattice that conducts electricity while neither component alone would.
Designing a small DNA origami that can fold in several almost equivalent ways demonstrates how understanding and guiding the folding pathway can improve the efficiency of the folding process, potentially leading in more complex situations to higher yields of the desired nanostructure and fewer misfolded structures.
Programmed assembly and disassembly of rigid 3D DNA origami objects has been achieved by designing complementary surface shapes based upon weak stacking interactions to create simple nanomachines.
