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Computational framework for structural DNA nanotechnology

A more general computational framework predicts the structures of 2D and 3D-curved DNA nanostructures impossible to predict using previously available computational methods. May lead to 3D-printing DNA nanostructures?

Large, open protein cages designed and built

Design principles have been developed and tested to construct novel synthetic protein monomers that can self-assemble into large, open protein cages for potential use in vaccines and drug delivery.

Using DNA nanotechnology to cast arbitrarily shaped nanoparticles

Metal or other inorganic nanoparticles of 20 to 30-nm scale can be cast in arbitrary 3D shapes and configurations dictated by stiff, atomically precise molds constructed using scaffold DNA origami.

DNA nanotechnology and the atoms to micrometer nanofabrication gap

A new DARPA program seeks to bridge the gap from atoms to macroscale product manufacture in two steps, the first of which is from atoms to micrometer-scale feedstocks. DNA origami may be part of the solution.

Proof of principle for nanoscale assembly line

Swiss researchers have used biomolecular shuttles to capture molecular building blocks from solution and transport them across fluid flow boundaries to be further manipulated in a subsequent chamber.

Lipid coat protects DNA nanorobot from immune attack

Enveloped DNA nanostructures were developed to escape attacks from nucleases and the immune system, opening a path to ever more sophisticated DNA nanomedical devices.

Bigger, stiffer, roomier molecular cages from structural DNA nanotechnology

Using struts made of DNA to stiffen polyhedral corners, scientists have build rigid DNA cages an order of magnitude larger than previous DNA nanostructures, and only one order of magnitude smaller than bacterial cells.

DNA nanotechnology positions components to optimize single-molecule fluorescence

A pillar constructed and positioned using DNA nanotechnology holds two gold nanoparticles and a dye molecule to enhance fluorescence over a hundred fold.

Reviews of DNA nanotechnology-atomically precise microscale objects

Two open access reviews portray the widening approach of DNA nanotechnology toward more complex atomically precise systems.

Mass production of higher quality oligonucleotides to spur DNA nanotechnology

Biotechnology-based isolation and amplification of sequence-verified clones of DNA oligonucleotides will provide longer and less expensive materials for building complex DNA nanostructures and nanomachinery.

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