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DNA nanomachine lights up to diagnose diseases

DNA nanotechnology produces an artificial molecular machine that changes shape when it encounters a specific antibody or other protein molecule, and emits light to signal the target’s presence.

Nanotechnology carries gene editing package into cells

Hijacking a viral method of replicating circular genomes, ball-of-yarn-like DNA clews are used to transport the protein and guide RNA molecules needed for gene editing into the cell nucleus.

Parallel to protein folding improves DNA origami process

Designing a small DNA origami that can fold in several almost equivalent ways demonstrates how understanding and guiding the folding pathway can improve the efficiency of the folding process, potentially leading in more complex situations to higher yields of the desired nanostructure and fewer misfolded structures.

Automated design of polyhedral meshes for DNA origami

An automated design process folds arbitrary meshes to produce DNA origami structures difficult to design by previous methods, including more open structures that are stable in ionic conditions used in biological assays.

Arranging molecular chromophores on DNA brick nanobreadboards

Nanobreadboards made of DNA bricks provide twice the positional precision, twice the packing density, and faster prototyping than do alternative means to arrange functional molecules.

Foresight co-sponsors Berkeley Bench to Market event

To educate potential entrepreneurs on strategies for moving discoveries from the benchtop to successful commercialization, Foresight co-sponsored an event in the “Ph.D. to Startup” Workshop Series of the Berkeley Postdoc Entrepreneur Program.

Linking together small DNAs to build more diverse DNA nanostructures

Using the enzyme DNA ligase and small DNA strands as building blocks provides an efficient and less expensive path to a large variety of DNA scaffolds and other structures.

DNA nanomachines more stable than expected in human serum and blood

Even without special designs and coatings to promote stability, simple DNA nanomachines can survive in human serum and blood for hours or even days, much longer than expected from previous studies using bovine serum, which has more damaging nucleases than does human serum.

Preserving protein function in DNA-protein nanostructures

Linking proteins to DNA scaffolds to produce complex functional nanostructures can require chemistry that damages protein function. A new systematic approach avoids exposing proteins to damaging conditions.

Solid-phase synthesis of custom-made DNA nanotubes

Single-molecule spectroscopy makes possible adding one rung at a time to a foundational rung grafted to a surface to make a long nanotube scaffold of predetermined sequence.

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