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Robust triangular RNA brick adds to RNA nanotechnology toolkit

The complex molecular recognition code of RNA offers RNA nanotechnology a greater variety of 3D structures and functions than are present in DNA nanotechnology, but the RNA structures can be fragile. New RNA triangles that resist boiling solve this problem.

Bigger, stiffer, roomier molecular cages from structural DNA nanotechnology

Using struts made of DNA to stiffen polyhedral corners, scientists have build rigid DNA cages an order of magnitude larger than previous DNA nanostructures, and only one order of magnitude smaller than bacterial cells.

Will crowdsourced RNA designs advance nanotechnology?

A very large community of online gamers has consistently produced RNA designs that outperform the best design algorithms by a large margin. Can online gamers designing RNA, protein, and other molecules contribute to the development of atomically precise manufacturing?

DNA nanotechnology positions components to optimize single-molecule fluorescence

A pillar constructed and positioned using DNA nanotechnology holds two gold nanoparticles and a dye molecule to enhance fluorescence over a hundred fold.

Reviews of DNA nanotechnology-atomically precise microscale objects

Two open access reviews portray the widening approach of DNA nanotechnology toward more complex atomically precise systems.

Mass production of higher quality oligonucleotides to spur DNA nanotechnology

Biotechnology-based isolation and amplification of sequence-verified clones of DNA oligonucleotides will provide longer and less expensive materials for building complex DNA nanostructures and nanomachinery.

Re-engineering a junction to give a new twist to DNA nanotechnology

By forcing the geometry of the junctions upon which DNA nanotechnology depends, researchers have increased the collection of 2D and 3D structures that they can build to include wire frames and mesh structures.

Arbitrarily complex 3D DNA nanostructures built from DNA bricks

A set of 32-nucleotide single strand DNA bricks was designed so that each can interact independently with four other DNA bricks so that sets of hundreds of bricks can self-assemble into arbitrarily complex 25-nm 3D shapes, each comprising 1000 8-base pair volume elements.

Biological molecular motors programmed to run DNA chasis

Two types of biological molecular motors that run in opposite directions along a protein track can be used in different arrangements to either move a complex DNA cargo along the track or engage in a tug-of-war.

Assembling biomolecular nanomachines: a path to a nanofactory?

A “cut and paste” method uses an atomic force microscope to assemble protein and DNA molecules to form arbitrarily complex patterns on a surface. Developing this approach to form enzymatic assembly lines could be a path toward a general purpose nanofactory.

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