Mapping the Brain’s Wiring Diagram at Industrial Scale

Understanding how the brain works — and what goes wrong in disease — requires knowing how its 86 billion neurons are connected. For the first time, we have a technology capable of doing this at scale. NeuroPEEM (Photoelectron Emission Microscopy) is a new approach to electron microscopy that images brain tissue over 300× faster and cheaper than existing methods. In this talk, I will describe the science behind connectomics, why scale has been the central unsolved problem, and how NeuroPEEM changes the equation — with implications for neuroscience, psychiatry, and the future of AI.