Brain Wiring through the Genomic Bottleneck

Animals are born with highly structured brain connectivity, which equips them with the ability tofunction well soon after birth with little or no experience. Because the wiring diagram is far too complexto be specified explicitly in the genome, it must be compressed through a “genomic bottleneck”. I willdiscuss theoretical and experimental results regarding the nature of the rules governing the genomicbottleneck and how high-throughput molecular connectomics based on new sequencing technologies can help uncover these rules.