Deep Learning for Neuronal Rejuvenation: Decoding the Transcriptomic Logic of Cellular Resilience

Parkinson’s strikes when aging brain cells lose their ability to repair themselves. We are training AI models to analyze massive datasets of cell images and gene activity. Our goal is to predict precise gene combinations that “reset” a neuron’s biological clock to a youthful, resilient state without causing damage, halting disease progression.

Biography

Alexander LeNail is a researcher at the Wyss Institute at Harvard and founder of the Arcanist Foundation, developing gene therapies for age-related neurodegenerative diseases including Parkinson’s, Alzheimer’s, and ALS. He holds a degree from Tufts and trained in the Heiman Lab at MIT, where he used AI to identify genes that bolster aging neurons’ resilience — and is now engineering therapies to activate them.