CALERIE Trials: Long-term Caloric Restriction on DNA methylation of Biological Aging

Geroscience has developed an arsenal of tools and interventions that can slow or even reverse biological aging in model organisms. Yet, the extent to which these interventions translate to humans is still unclear. A major obstacle to the testing geroprotective interventions in humans is the latency between treatment and conventional measures of biological aging. In this talk, I will discuss measures of biological aging, with a focus on epigenetic clocks derived from DNA methylation, and how these tools are changing the face of translational research on aging. I will highlight strengths and limitations of epigenetic clocks, and then explore their application in the first long-term, randomized controlled trial of caloric restriction in healthy non-obese humans.