Quantifying Aging
With Vadim Gladyshev
With the rapid expansion of aging biology research, identification and evaluation of longevity interventions in humans have become key goals of this field. Biomarkers of aging are critically important tools in achieving these objectives over realistic timeframes. Here, we advance a framework for characterizing and assessing biomarkers of aging, including consensus terminology for several key concepts in this space. We propose classification of existing biomarkers and evaluate their feasibility, age-sensitivity, mechanistic underpinnings, and response criteria. We also discuss analytical and clinical validation of biomarkers of aging, including validation as surrogate endpoint biomarkers of clinical outcomes. This framework sets the stage for the future development of valid biomarkers of aging and their ultimate utilization in clinical trials and practice.