Vadim Gladyshev is a Professor of Medicine at Harvard Medical School, Director of the Center for Redox Medicine at Brigham and Women's Hospital, and Associate Member of the Broad Institute. Dr. Gladyshev’s lab focuses on studying aging, rejuvenation and lifespan control using a combination of experimental and computational approaches. He has published more than 400 articles. Dr. Gladyshev is the recipient of NIH Pioneer, Transformative and Eureka awards and is an elected member of the National Academy of Sciences, USA.
Mahdi Moqri is an NIH Postdoctoral Fellow in Aging Research at the Sebastiano Lab at the Institute for Stem Cell Biology and Regenerative Medicine at Stanford, and a visiting scholar at the Gladyshev Lab at Harvard Medical School. His current research is on epigenomics of aging and rejuvenation.
Vittorio Sebastiano is an Associate Professor (Research) of Obstetrics and Gynecology (Reproductive and Stem Cell Biology) at Stanford University. He is an in expert in Stem Cells, Developmental Biology, Molecular Biology, Tissue Engineering, Genome Editing, Cell Culture, and Immunohistochemistry.
With the rapid expansion of aging biology research, identification and evaluation of longevity interventions in humans have become key goals of this field. Biomarkers of aging are critically important tools in achieving these objectives over realistic timeframes. Here, we advance a framework for characterizing and assessing biomarkers of aging, including consensus terminology for several key concepts in this space. We propose classification of existing biomarkers and evaluate their feasibility, age-sensitivity, mechanistic underpinnings, and response criteria. We also discuss analytical and clinical validation of biomarkers of aging, including validation as surrogate endpoint biomarkers of clinical outcomes. This framework sets the stage for the future development of valid biomarkers of aging and their ultimate utilization in clinical trials and practice.