Unrelated de novo enzyme replaces essential enzyme in cell
Iron-rich medium supports the growth of E. coli engineered to no longer have a natural Fes enzyme. They form small, unhealthy, red colonies because they accumulate iron bound to [...]
Iron-rich medium supports the growth of E. coli engineered to no longer have a natural Fes enzyme. They form small, unhealthy, red colonies because they accumulate iron bound to [...]
Image Credit: 3DSculptor / Shutterstock.com The Foresight Institute was founded in 1986 on a vision presented by Eric Drexler in which the ultimate manufacturing technology uses a machine termed [...]
It’s not red and white, but the atoms are arranged in the shape of a Swiss cross (Credit: Physics department, University of Basel) If the above picture reminds you [...]
Since winning the 2007 Foresight Institute Feynman Prize in Nanotechnology, Theory category, Professor David Leigh FRS FRSE FRSC MAE, and since 2012 at the University of Manchester, has continued to [...]
A review from the group leading recent rapid progress in de novo protein design describes the successes, identifies the remaining challenges, and heralds the advance "from the Stone Age to the Iron Age" in protein design.
A new funding opportunity from the Advanced Manufacturing Office, U.S. Department of Energy, incudes a subtopic on Atomically Precise Manufacturing
Longtime Foresight member Dave Forrest is leading DOE's Advanced Manufacturing Office in advocating atomically precise manufacturing to transform the U.S. manufacturing base.
An automated design process folds arbitrary meshes to produce DNA origami structures difficult to design by previous methods, including more open structures that are stable in ionic conditions used in biological assays.
Designing and building spiroligomers, robust building blocks of various 3D shapes made from unnatural amino acids, decorated with various functional groups, and linked rigidly together by pairs of bonds, and a new approach to nanotechnology design software.
Linking proteins to DNA scaffolds to produce complex functional nanostructures can require chemistry that damages protein function. A new systematic approach avoids exposing proteins to damaging conditions.