A review from the group leading recent rapid progress in de novo protein design describes the successes, identifies the remaining challenges, and heralds the advance "from the Stone Age to the Iron Age" in protein design.
A new funding opportunity from the Advanced Manufacturing Office, U.S. Department of Energy, incudes a subtopic on Atomically Precise Manufacturing
Longtime Foresight member Dave Forrest is leading DOE's Advanced Manufacturing Office in advocating atomically precise manufacturing to transform the U.S. manufacturing base.
An automated design process folds arbitrary meshes to produce DNA origami structures difficult to design by previous methods, including more open structures that are stable in ionic conditions used in biological assays.
Designing and building spiroligomers, robust building blocks of various 3D shapes made from unnatural amino acids, decorated with various functional groups, and linked rigidly together by pairs of bonds, and a new approach to nanotechnology design software.
Linking proteins to DNA scaffolds to produce complex functional nanostructures can require chemistry that damages protein function. A new systematic approach avoids exposing proteins to damaging conditions.
A European Science and Technology Roadmap for Graphene, Related Two-Dimensional Crystals, and Hybrid Systems hints at the opportunities to be harvested from, and the need for, the development of atomically precise manufacturing (APM).
Design and computational simulation of amyloid proteins of diverse functions from diverse sources enable the self-assembly of proteins that could provide scaffolds for diverse applications.
A commentary over at Gizmodo argues that ideas about molecular manufacturing that sounded like science fiction in 1986 now sound more like science fact.
The idea that nanorobots fabricated by atomically precise manufacturing processes are a likely part of our future, and that this is a good thing, is appearing more frequently, largely as a result of Drexler's recent book Radical Abundance.
