Confocal microscope allows imaging 3D imaging of cellular structures

Gina Miller writes "Luke P. Lee, assistant professor of bioengineering at UC Berkeley, and his doctoral student Sunghoon Kwon have developed a miniature microlens and scanner that can see inside of a cell. "You could put this device on the tip of an endoscope that could be guided inside a cancer patient," said Lee. "Doctors could then see how tumor cells behave in vivo. It would also be feasible to deliver drugs directly to the tumor cell, and then view how the cell responds to the drugs." See the Berkeley Campus news site (3/13/02): http://www.berkeley.edu/news/media/releases/2002/0 3/13_micro.html"

eru writes "[The] press release from UC Berkeley details a proof-of-concept experiment wherein UC Berkeley professor Luke Lee successfully imaged (in 2-D) a lily's cell wall using a combination microlens and scanner, two devices which Lee has stated that he plans to incorporate into a fully miniaturized 3-D microscope in the future."

And Mr_Farlops points to additonal coverage in which "Science Daily reports that researchers at UC Berkeley have built a working array of confocal optical scanners, each one millimeter in size, built with photolithography methods. They plan to build even smaller devices and imagine uses in materials science, microscopic medical robots, cytology and microbiological research. Obviously such devices acting as the eyes of microscopic medical robots will revolutionize medicine even before nanoscopic cell repair robots arrive. I also personally find it significant that the article notes that this development is funded by, in part, by DARPA."

Read more for a longer post in this item from Brian Wang.

More interesting items from MEMS 2002 Conference

Following up on a previous Nanodot post (22 January 2002), here are a few additional items of interest to emerge from the MEMS 2002 Conference co-sponsored by the Institute of Electrical and Electronics Engineers (IEEE) and the Robotics and Automation Society, and held 20-24 January 2002 in Las Vegas, Nevada:

Many of these UPI stories, as well as much original coverage of the conference, appeared on the Small Times website.

Explosive silicon in MEMS?

Mr_Farlops writes "Serendipity struck for chemists at the University of California, San Diego, after a chip of porous silicon, laced with gadolinium nitrate, exploded after being scratched. An article in the EE Times describes the nature of this discovery and speculates about the possible uses of the substance in microscopic rockets and explosive charges. It also sets the mind daydreaming about tiny fuses made of nested nanotubes filled with fuel and oxidizers."

MEMS 2002 Conference also looks at nanoscale devices

Amid the conference focused on microdevices, some interesting nanotech-related news emerged from the MEMS 2002 Conference co-sponsored by the Institute of Electrical and Electronics Engineers (IEEE) and the Robotics and Automation Society, and held 20-24 January 2002 in Las Vegas, Nevada. A good general overview of the conference appeared on the Small Times website ("Record numbers at MEMS conference", by Jane Fried, 22 January 2002). Some of the highlights include:

Sandia creates MEMS device to catch blood cells

from the getting-cute-with-PR dept.
The press accounts indicate that a lot of people are just ga-ga over the silicon micro-device developed at Sandia National Labs. Described as a "Pac-Man-like microstructure" and the "gobbler", the device has silicon microteeth that open and close like jaws. The microjaws fit in a microchannel about one-third the width of a human hair (about 20 microns wide). When the jaws close, they trap a red blood cell. According to a Sandia press release on 20 August 2001, "The jaws, which open and close very rapidly, deform captured cells, and then, in less than the blink of an eye and almost playfully, let the little things loose. The blood cells travel on, regain their former shape and appear unharmed." [Playfully?]
Additional coverage can be found in this article from UPI. And Robert Trombatore writes: "A news item on the Scientific American web site details a just announced microdevice that can grab individual red blood cells flowing through a central channel. So far no practical uses, but the article mentions a few intriguing possibilities!"

Smart Sensor "Dust"

TanMauWu writes "Wired has a story about "smart dust" that researchers at UC Berkeley have developed, which are essentially tiny light and temperature sensors that can network together. The suggested use for these sensors is to put lots of them in every room in a building and tie them all to a main computer that can regulate energy usage in the building to save energy. Of course, we can all think of *other* possible uses for this, can't we? Not quite true utility fog, but we're getting there."

The Future of MEMS is NEMS

from the Big-bugs-have-little-bugs dept.
Waldemar Perez calls our attention to an article on NanoElectroMechanical Systems (NEMS) in Technology Review Magazine ("NEMS: Machines Get Tiny," by David Voss, April 2001). In his opinion, Mr. Perez writes, "NEMS research promises to give us machines on the nanometer scale, [but this is] exactly there were critics argue Brownian motion will destroy them or make these machines unworkable and unreliable . . . these first generation NEMS prototypes will suffer from high wear (a well known problem on MEMS) until we can incorporate into them Drexler-type nanobearings and other devices."

Casimir force used by MEMS, will affect nanotech

from the top-down-pathway dept.
ScienceExpress, an online preprint service (login req'd) of Science magazine, published on Feb. 8 a report from Bell Labs/Lucent that MEMS can exploit the Casimir force. Coauthor Federico Capasso was quoted in the Feb. 10 Science News: "Capasso speculates that makers of MEMS and even tinier nanoelectromechanical systems may find ways to harness the Casimir force in 5 to 15 years…the experiment also indicates that the Casimir effect may become problematic for designers of tiny machines, says Paul J. McWhorter of MEMX…" CP: What's problematic to some may be a fun challenge to others — anyone care to give their view on this? Read more for the abstract.

Very Large Scale Integration for MEMS

from the thousands-of-steps-will-get-somewhere dept.
SteveLenhert writes "Integration of basic MEMS components is bridging the gap between micro- and nanotechnology. Very Large Scale Integration (VLSI) of basic electronic components such as diodes and transistors is well established. This article on Mechanical VLSI describes approaches to (and implications of) VLSI of mechanical components such as actuators and cantilevers.

NEMS history and challenges

from the take-it-from-the-top-down dept.
Waldemar Perez writes "This is one of the most interesting articles I have found on NEMS. It was published in Physics World magazine and talks about some early NEMS working prototypes and the challenges facing NEMS.

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