During this session, three speakers shared their opinion on what are the underappreciated opportunities in the field of aging and the work that is currently not well incentivized but could dramatically advance the progress. Mike West discussed the need for treatments of chronic degenerative diseases associated with aging and the potential of partial reprogramming for induced tissue regeneration. Karl Pfleger described the need for better “debuggers for biological blackboxes”, also the need for trialing combinations of therapies and aiming for robust mouse regeneration, as well as the overlooked opportunity of the professional sports market for longevity. Sonia Arrison mentioned immune system regeneration, regenerative medicine and organ repair, as well as more focus on the brain enabled by a novel focus on brain research. Then the group together discussed a range of interesting ideas for instrumentation and tooling that could advance progress in the field, and also roadblocks and concerns that the community needs to be wary of, with a few concrete examples of what the field can do to prevent them.