Video
Transcript
Slides

Session report

James Cooper’s introduction.  Do look at the Slides.  They have pictures of many recent molecular systems and experiments.  Here is the text from the slides.

  • What is a Molecular Machine?
    • Out-of-equilibrium states
    • Molecular assembler
    • Molecular manufacturing
    • Unidirectional motion
    • Directed molecular motion
    • “Machine-like” behaviour
    • Processivity
    • Motors
    • Ability to perform work
    • Switches
    • Single molecule computing
    • Translocation of molecular cargo
  • What are the Future Challenges for Molecular Machines?
    • Identify the fundamental concepts that govern how molecular machines behave
    • Interfacing molecular machines with nano- or microscale assemblies
    • Molecular machines operating in concert
    • Applications of Molecular Machines
    • Cycle:  Design, Operation, Evaluation, Optimization, leads to Machines that can produce useful work.
    • Compartmentalisation 
    • Integration with materials
    • Macro-level properties?
    • Out-of-equilibrium behaviour in molecular networks
    • Construct molecular systems that display ‘life-like’ properties
    • Healthcare technology
    • Molecular manufacturing
    • Energy solutions
    • Molecular Computing
  • Synthetic Molecular Machines, Potential Challenges to Address
    • Increase theoretical understanding?
    • More efficient operation? Autonomy?
    • More minimal designs?
    • Way to leverage work produced?
  • Materials and Molecular Machines, Potential Challenges to Address
    • Leverage incorporation into materials?
    • Compartmentalization
    • Produce gradients → useful work?
  • Membrane-bound Molecular Machines
  • Molecular and Molecule Machines on Surfaces, Potential Challenges to Address
    • Fundamental lessons still to learn?
    • Force exerted by machines?
    • Greater control over single molecules?
  • Molecular Assemblers, Potential Challenges to Address
    • Reload track (non-destructive)?
    • Construction of oligomers? Robustness?
    • Greater diversity of chemistries per assembler?
  • Repurposing Biology, Potential Challenges to Address
  • Designing protein-based molecular machines?
  • Inform design of organic synthetic molecular machines?
  • Limitations? Complementary to organic synthetic analogues?
  • Networks, Technology and Out-of-Equilibrium Assembly, Potential Challenges to Address
    • Networked molecular machines?
    • Coupling molecular networks with compartments?
    • Machines that respond to feedback loops?
    • Computational planning of machine synthesis?