Spiroligomers are a powerful platform technology that enables the creation of artificially-designed, large molecules with diverse applications. These molecules can be used as therapeutics by binding to specific proteins, as catalysts that convert inexpensive raw materials into high-value products, and ultimately as the building blocks of molecular machines. In this discussion, I will provide an overview of the underlying technology and highlight several examples of its use. I will demonstrate how spiroligomers are being developed to replace monoclonal antibodies in diagnostic tests, and how they can be utilized to create highly-efficient catalysts. Lastly, I will delve into the potential of spiroligomers to create complex molecular machines.