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Gaming the Future: The Book!

Controlling the Motion of DNA Gliders

  • October 29, 2022

Presenters

Tyler Ross, researcher at Caltech

Postdoctoral Researcher at Caltech in DNA Nanotech

Matteo Guareschi, grad student at Caltech

Graduate Student in Bioengineering at Caltech

Summary:

Tyler Ross, researcher at Caltech and Matteo Guareschi, grad student at Caltech are engineering molecular motors to respond to light. The motors cluster together when light is shined on them, assembling large aggregations of microtubles in the process. Iterating on this concept, he attached the motor proteins to a glass surface and allowed the microtubules to move freely over the surface of motors. The issue now is how to program controlled movement into the process to create gliders. One way to do this is to replace the microtubule glider with DNA, which can be programmed and engineered into highly unique conformations. DNA fabrics, like those being built by William Shih, may be able to be programmed to have complex motion and could unlock new possibilities for this mechanism.

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