Presenter
Diana Guallar, CiMus
Diana holds a PhD in Cellular Biology by the University of Zaragoza (Spain). Her thesis was focused on the study of epigenetic regulation of endogenous retroviruses in embryonic pluripotent stem cells...
Summary:
Diana researches epitranscriptomics – the epigenetic modifications to RNA and the defining step between DNA and protein translation.Ā Broadly speaking, epitranscriptomics falls within the domain of epigenetics and the cellular reprogramming approach to aging.
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Currently, epitranscriptomics is not included in the hallmarks of aging.Ā However, these reversible processes govern many interactions that occur upstream of the various hallmarks and represent a new unique target for clinical aging interventions.Ā Epitranscriptomics regulate transposable element function, which include retrotransposons such as LINE-1 and ERV.Ā Transposable element expression increases with age and is associated with progeroid syndromes.Ā Diana also discovered a key editing schema involving ADAR1 that is required for cell reprogramming.
In the future, she hopes to discover a method for generalized epitranscriptomic rejuvenation.
Slides:
