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Gaming the Future: The Book!

Linna An, postdoc at University of Washington | De Novo Design of Small Molecule Binding Proteins

  • October 29, 2022

Presenter

Linna An, postdoc at University of Washington

I design protein binders for small molecules and peptide binders for protein complexes.

Summary:

Linna An, postdoc at University of Washington, describes the process of designing small molecules that bind to proteins. The canonical method involved generating scaffolds, designing the ligand docking, designing docks, designing filters, then finally testing in the lab. However, there are difficulties with finding ideal ligand designs because small molecules have such low tolerances. This problem can be solved using deep learning computation to improve every step of the design process. Linna’s group is incorporating AlphaFold 2, RosettaFold, and Rosetta to dramatically speed up small molecule discovery.

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