Reason, CEO of Repair Biotechnologies, brought an extended complaint about gene therapy to the stage. Gene therapy is the process of replacing or altering the genome within cells, and has the potential to solve all sorts of pathologies. It could also let us figure out the core mechanics of aging, but all the current methods of gene therapy are too flimsy to use properly. We need a gene therapy that works 8-out-of-10 times, something robust and reliable. Critical features of such a therapy would include tissue or cell specific targeting, access to the nucleus or mitochondria, low immunogenicity, and tunable duration of expression.