Xinru Wang, postdoc at University of Washington, stepped in for her colleage to describe the process of designing proteins that bind to receptors. She uses insulin as an example – one of the most useful and widespread prescribed proteins on the market today. Xinru designed an insulin substitute using RifGen and a scaffold library, simulating various motifs for testing via a high-throughput screen. Computational simulation and previously constructed protein libraries are key to rapidly designing and testing protein binding prior to the slower wetlab phase.