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Gaming the Future: The Book!

Category: Nanobiotechnology

Nanotechnology milestone: general method for designing stable proteins

Five proteins were designed from scratch and found to fold into stable proteins as designed, proving the ability to provide ideal, robust building blocks for artificial protein structures.

More complex circuits for synthetic biology lead toward engineered cells

One possible pathway from current technology to advanced nanotechnology that will comprise atomically precise manufacturing implemented by atomically precise machinery is through adaptation and extension of the complex molecular machine systems evolved by biology. Synthetic biology, which engineers new biological systems and function not evolved in nature, is an intermediate stage along this path. An… Continue reading More complex circuits for synthetic biology lead toward engineered cells

Shape may play an important role in nanoparticle-based therapeutics

Researchers from Johns Hopkins and Northwestern Universities developed a set of shape-tunable DNA-copolymer nanoparticles that incorporate a fixed amount of DNA yet display as much as 1,680-fold difference in transfection efficiency in rat liver studies. The study may shed new light on the importance of shape in nanoparticle-based drug delivery and gene therapy.

Biological molecular motors programmed to run DNA chasis

Two types of biological molecular motors that run in opposite directions along a protein track can be used in different arrangements to either move a complex DNA cargo along the track or engage in a tug-of-war.

Nanoparticles deliver cargo inside mitochondria

Optimizing the size and charge of nanoparticles engineered from polymers delivers drugs directly to mitochondria, effectively treating cells with drugs for a variety of diseases.

Assembling biomolecular nanomachines: a path to a nanofactory?

A “cut and paste” method uses an atomic force microscope to assemble protein and DNA molecules to form arbitrarily complex patterns on a surface. Developing this approach to form enzymatic assembly lines could be a path toward a general purpose nanofactory.

Rational design of peptoids: a route to advanced nanotechnology?

A combination of theoretical and experimental work on peptoids, synthetic analogs of proteins, points to the ability to design peptoids with desired structures and functions.

Shear-activated nanoparticles may target blood clots

Studies in mice with otherwise fatal blood clots have shown that targeting a clot-busting drug to regions where blood flow is blocked restores circulation and increases survival with a much lower, safer dose of the drug.

Toward a method to design any needed catalyst?

Computational insights into a fundamental organic synthesis reaction may lead to the ability to design a catalyst for any desired reaction.

Artificial evolution of enzymes to make novel semiconductors

The directed, artificial evolution of genes for enzymes that produce nanoparticles of silicon dioxide and titanium dioxide produced semiconductor structures not seen in nature.

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