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Gaming the Future: The Book!

Category: Research

Ribosome subunits tethered to make versatile artificial molecular machine

Functional ribosomes with subunits engineered to not separate at the completion of each protein translation cycle make possible engineering systems to make a variety of novel polymers with novel properties.

Automated design of polyhedral meshes for DNA origami

An automated design process folds arbitrary meshes to produce DNA origami structures difficult to design by previous methods, including more open structures that are stable in ionic conditions used in biological assays.

Arranging molecular chromophores on DNA brick nanobreadboards

Nanobreadboards made of DNA bricks provide twice the positional precision, twice the packing density, and faster prototyping than do alternative means to arrange functional molecules.

Facilitating structural DNA nanotechnology with non-aqueous solvents

Recent research demonstrates that certain non-aqueous solvents can not only be used to assemble DNA nanostructures, but offer certain advantages over conventional aqueous solvents.

Conference video: Conformational and compositional dynamics of a molecular machine

At the 2013 Conference Joseph Puglisi described how single molecule fluorescence techniques were used to study changes in the conformation and composition of the ribosome, a large biomolecular nanomachine, during the process of translation of genetic information.

Linking together small DNAs to build more diverse DNA nanostructures

Using the enzyme DNA ligase and small DNA strands as building blocks provides an efficient and less expensive path to a large variety of DNA scaffolds and other structures.

Toward advanced nanotechnology: Working solid state molecular shuttle

A molecular ring shuttles back and forth between two positions on a molecular axle held rigidly inside a solid state molecular lattice made from a metal organic framework.

Wafer-scale atomically precise thin layers for nanotechnology

By precise control of several factors, uniform high-performance monolayers of the semiconductor MoS2 have been obtained and used to fabricate field-effect transistors.

DNA nanomachines more stable than expected in human serum and blood

Even without special designs and coatings to promote stability, simple DNA nanomachines can survive in human serum and blood for hours or even days, much longer than expected from previous studies using bovine serum, which has more damaging nucleases than does human serum.

Google Tech Talk video by Feynman Prize Winner

Designing and building spiroligomers, robust building blocks of various 3D shapes made from unnatural amino acids, decorated with various functional groups, and linked rigidly together by pairs of bonds, and a new approach to nanotechnology design software.

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