We found 164 results for your search.

De novo protein design space extends far beyond biology

A fully automated design protocol generates dozens of designs for proteins based on helix-loop-helix-loop repeat units that are very stable, have crystal structures that match the design, have very different overall shapes, and are unrelated to any natural protein.

Dynamic nanomachines for DNA nanotechnology inspired by proteins

Programmed assembly and disassembly of rigid 3D DNA origami objects has been achieved by designing complementary surface shapes based upon weak stacking interactions to create simple nanomachines.

New scaffold for nanotechnology engineered from amyloid-like proteins

Design and computational simulation of amyloid proteins of diverse functions from diverse sources enable the self-assembly of proteins that could provide scaffolds for diverse applications.

Small molecule nanorobot walks through a protein nanopore

Among the smallest molecular robots reported so far, a walker based on phenylarsonous acid with two organic thiol ligands as feet walks through a one-nanometer-diameter protein nanopore channel by taking 0.6 nanometer steps, by thiol exchange, from one cysteine residue to the next.

Computational design of protein-small molecule interactions

A major advance in the computational design of proteins that bind tightly to specific small molecules will facilitate several technologies, possibly including the development of atomically precise manufacturing.

Nanotechnology milestone: general method for designing stable proteins

Five proteins were designed from scratch and found to fold into stable proteins as designed, proving the ability to provide ideal, robust building blocks for artificial protein structures.

Advancing nanotechnology with protein building blocks

A variety of protein cage structures have been constructed by designing specific protein domains to self-assemble as atomically precise protein building blocks in defined geometries.

Engineered bacteria provide new tool for nanotechnology protein design

Engineered bacteria that incorporate unnatural amino acids at multiple positions provide a new tool that may facilitate designing proteins to fold more predictably into molecular machinery components.

Designing protein-protein interactions for advanced nanotechnology

Progress in computational modeling of protein structures and in designing protein interfaces that bind in a desired geometrical orientation prepare the way for designing protein components of molecular machine systems.

Protein, RNA, DNA: Nanotechnology finds a multitude of paths to attack cancer cells

Protein, RNA, DNA provide very different molecular architectures for nanotechnology to adopt to deliver drugs to cancer cells while sparing healthy cells.

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