Review of artificial molecular machines and their controlled motions

An extensive review of artificial molecular machines, their large-amplitude motions, and the changes these motions produce, emphasizes small molecules and the central role of chemistry in their design and operation.

Addressable molecular machines arranged in a porous crystal

Simple molecular switches based upon bistable mechanically interlocked molecules can be incorporated within pre-assembled metal organic frameworks and addressed electrochemically.

Overview of molecular machines documents recent progress

A review of molecular parts that act as switches, motors, and ratchets illuminates similarities between artificial and biological molecular machines and argues that useful applications are coming.

Macroscopic mechanical manipulation controls molecular machine array

A pliers-shaped molecule in which two covalently linked naphthalene moieties serve as the hinge connecting the two halves of the pliers, and each naphthalene connects the hydrophobic handle with the hydrophilic jaw of that half, opens and closes in response to surprisingly little energy applied to a molecular monolayer.

Conference video: Artificial Biochemistry with DNA

Modeling DNA strand displacement cascades according to three simple rules can in principle mimic the temporal dynamics of any other chemical system, presenting a method to model regulatory networks even more complicated than those of biology.

Ribosome subunits tethered to make versatile artificial molecular machine

Functional ribosomes with subunits engineered to not separate at the completion of each protein translation cycle make possible engineering systems to make a variety of novel polymers with novel properties.

Conference video: Conformational and compositional dynamics of a molecular machine

At the 2013 Conference Joseph Puglisi described how single molecule fluorescence techniques were used to study changes in the conformation and composition of the ribosome, a large biomolecular nanomachine, during the process of translation of genetic information.

Toward advanced nanotechnology: Working solid state molecular shuttle

A molecular ring shuttles back and forth between two positions on a molecular axle held rigidly inside a solid state molecular lattice made from a metal organic framework.

Conference video: Regenesis: Bionano

At the 2013 Conference George Church presented an overview of his work in developing applications of atomically precise nanotechnology intended for commercialization, from data storage to medical nanorobots to genomic sequencing to genomic engineering to mapping individual neuronal functioning in whole brains.

Dynamic nanomachines for DNA nanotechnology inspired by proteins

Programmed assembly and disassembly of rigid 3D DNA origami objects has been achieved by designing complementary surface shapes based upon weak stacking interactions to create simple nanomachines.

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