Protein design provides a novel metabolic path for carbon fixation

Computational design of an enzyme that carboligates three one-carbon molecules to form one three-carbon molecule, an activity that does not exist in nature, provides proof-of-principle for a novel metabolic pathway for carbon fixation.

Triple helices stabilize macroscopic crystals for DNA nanotechnology

A DNA strand capable of forming a triple helix with a portion of the DNA double helices in a macroscopic DNA crystal enhances the weak interactions holding the crystal together so that the crystal remains stable in the absence of a high ionic strength environment.

Macroscopic DNA crystals from molecular tensegrity triangles

Structural DNA nanotechnology: progress toward a precise self-assembling three dimensional scaffold by building macroscopic crystals from nanoscale structures.

Five ionized atoms provide scalable implementation of quantum computation algorithm

Five calcium ions held several micrometers apart in an ion trap and manipulated by laser pulses implement Shor’s factorization algorithm more efficiently than previous implementations.

Will medical 3D printing advance nanotechnology?

Do sophisticated medical applications of 3D printing, like printing titanium bones or human tissues, that portend wider use, also perhaps point toward eventual nanoscale applications as the technology improves?

Tightly-fitted DNA parts form dynamic nanomachine

A rotor with DNA origami parts held together by an engineered tight fit instead of by covalent bonds can revolve freely, driven by Brownian motion and dwelling at engineered docking sites.

Multiple advances in de novo protein design and prediction

New families of protein structures, barrel proteins for positioning small molecules, self-assembling protein arrays, and precision sculpting of protein architectures highlight de novo protein design advances.

Rational design of protein architectures not found in nature

Computational design of proteins satisfying predetermined geometric constraints produced stable proteins with the designed structure that are not found in nature.

De novo protein design space extends far beyond biology

A fully automated design protocol generates dozens of designs for proteins based on helix-loop-helix-loop repeat units that are very stable, have crystal structures that match the design, have very different overall shapes, and are unrelated to any natural protein.

DNA nanotechnology controls which molecules enter cells

DNA building blocks mimic biological ion channels to more precisely control which molecules can cross a biological membrane.

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