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Gaming the Future: The Book!

Category: Nanobiotechnology

Computational framework for structural DNA nanotechnology

A more general computational framework predicts the structures of 2D and 3D-curved DNA nanostructures impossible to predict using previously available computational methods. May lead to 3D-printing DNA nanostructures?

Artificial enzymes created from building blocks not found in nature

Artificial enzymes have been created from nucleic acids that use synthetic molecules instead of ribose or deoxyribose sugars.

Large, open protein cages designed and built

Design principles have been developed and tested to construct novel synthetic protein monomers that can self-assemble into large, open protein cages for potential use in vaccines and drug delivery.

Broadening the synthetic biology path to molecular nanotechnology

Advances in the de novo design of coiled-coil proteins made by two different research groups proceeding by two different routes demonstrate that the range of protein nanostructures potentially available for various molecular machine systems is significantly larger than the range of such structures already exploited by natural selection.

Micrometer-scale structures built from DNA bricks

A general framework is presented for using 32-nucleotide DNA bricks to build large two-dimensional crystals up to 80 nm thick and incorporating sophisticated three-dimensional features.

Using DNA nanotechnology to cast arbitrarily shaped nanoparticles

Metal or other inorganic nanoparticles of 20 to 30-nm scale can be cast in arbitrary 3D shapes and configurations dictated by stiff, atomically precise molds constructed using scaffold DNA origami.

DNA nanotechnology and the atoms to micrometer nanofabrication gap

A new DARPA program seeks to bridge the gap from atoms to macroscale product manufacture in two steps, the first of which is from atoms to micrometer-scale feedstocks. DNA origami may be part of the solution.

Scaffolded DNA origami improvements advance DNA nanotechnology

A 10-fold larger breadboard and 350-fold lower DNA synthesis costs make DNA origami a more useful stepping-stone toward atomically precise manufacturing.

Novel multifunctional nanoparticle for diagnosis and therapy

A nanoparticle that self-assembles from porphyrin, cholic acid, amino acids, and polyethylene glycol is a promising vehicle for delivering both imaging agents and cancer drugs to tumors.

Proof of principle for nanoscale assembly line

Swiss researchers have used biomolecular shuttles to capture molecular building blocks from solution and transport them across fluid flow boundaries to be further manipulated in a subsequent chamber.

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