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Presenter Alexis Courbet Alexis Courbet, PhD., PharmD., is an HHMI research associate at the institute for protein design (IPD), at the University of Washington’s School of Medicine. Dr. Courbet joined the IPD in 2016 to investigate computational approaches…. Alexis’s research proposes to investigate computational design rules to rationally install biochemical energy driven dynamic and mechanical… Continue reading Alexis Courbet | Towards Computational Design of Self Assembling &Genetically Encodable Nanomachines
30 Years of Foresight Timeline 1986 – 2016 Part I – The Ultimate Manufacturing Technology Part II – Promoting Understanding, Building Community Part III – A Roadmap Part IVI – Moving Toward a World of Human Flourishing Part I – The Ultimate Manufacturing Technology A. Founding Vision The Foresight Institute was founded… Continue reading Our History
Stephen Malina 2021 Foresight Fellow in Machine Learning for Virus & Protein Design Stephen is currently an ML scientist at Dyno Therapeutics (dynotx.com), where he’s working on applying machine learning to design better viral vectors for gene therapy. Immediately prior to joining Dyno, Stephen graduated from Columbia with an MS, during which he worked on… Continue reading Stephen Malina
HAPPENING AT FORESIGHT INSTITUTE September is coming to an end and a lot has been happening at Foresight: releasing new podcast episodes, opening our fellowship applications and creating some new seminar summaries for you to catch up on! We had our first gathering in Europe this month, thank you to everyone who joined us in Berlin. You can find the recordings of… Continue reading September update: Fellowship applications for 2022 are open! New seminar summaries! New podcast episodes!
HAPPENING AT FORESIGHT THIS MONTH There are so many exciting things going on at Foresight and we wanted to make sure you don’t miss any of the good stuff! We have a bunch of new podcast episodes, announcements of bounty winners and a whole lot of new seminar summaries for you to dive into, so here we go! SAVE… Continue reading A lot going on! Bounty winners, new podcast episodes, videos and seminar summaries from Foresight Institute
Summary David Baker from the University of Washington presents breakthrough advancements in de novo protein design. Deep learning pattern recognition hallucinates the desired protein structure and also generates the correct peptide sequence for accurate folding, and predicted proteins are highly transferable to actual proteins produced in a lab. Results are easily transferable to the production… Continue reading Protein-based Assemblies and Molecular Machines | David Baker, University of Washington
Summary James Cooper discusses The Foresight Institute, future directions and goals for the Molecular Machines group. We seek to create an inclusive community of forward thinkers and doers who are interested in nanotechnology. A fantastic array of projects and contributors is lined up and more interesting projects are always being added. Attend the online discussions… Continue reading Molecular Machines Group Launch | James Cooper, University of Reading
The first proposal of a path from then current technology to the ability to fabricate complex materials and devices by placing the atoms where you want them was made by Richard Feynman in 1959: “There’s Plenty of Room at the Bottom“, but see also this series “Feynman Path to Nanotechnology“. The second proposal to achieve… Continue reading Unrelated de novo enzyme replaces essential enzyme in cell
Protein design has been one of the major paths from current fabrication technology toward the goal of general purpose, high-throughput atomically precise manufacturing since Foresight co-founder Eric Drexler proposed it in 1981. It also produced some of the earliest promising results. Although de novo protein design was at first slow, progress has accelerated since David… Continue reading Design of hyperstable constrained peptides
In writing for this blog, I am accustomed to rapid changes from one technological area to another, such as from DNA origami to de novo protein design to scanning probe microscopy to molecular machinery based on mechanically interlocked molecular architectures. The DNA and protein work overlaps with biotechnology, and we have always seen all these… Continue reading Blockchains, Cryptoeconomics, and Emerging Technology Risks
