Linking together small DNAs to build more diverse DNA nanostructures

Using the enzyme DNA ligase and small DNA strands as building blocks provides an efficient and less expensive path to a large variety of DNA scaffolds and other structures.

DNA nanomachines more stable than expected in human serum and blood

Even without special designs and coatings to promote stability, simple DNA nanomachines can survive in human serum and blood for hours or even days, much longer than expected from previous studies using bovine serum, which has more damaging nucleases than does human serum.

Google Tech Talk video by Feynman Prize Winner

Designing and building spiroligomers, robust building blocks of various 3D shapes made from unnatural amino acids, decorated with various functional groups, and linked rigidly together by pairs of bonds, and a new approach to nanotechnology design software.

Conference video: Regenesis: Bionano

At the 2013 Conference George Church presented an overview of his work in developing applications of atomically precise nanotechnology intended for commercialization, from data storage to medical nanorobots to genomic sequencing to genomic engineering to mapping individual neuronal functioning in whole brains.

Nanoparticles shepherd DNA into cells to regulate immune response

DNA sequences designed to either stimulate a specific immune response or to down-regulate an undesirable response deliver superior performance when organized on nanoparticles to reach their intended cellular targets.

Gold nanotubes engineered for diagnosis and therapy

Gold nanotubes engineered to a specified length, modified surfaces, and to have other desirable characteristics showed expected abilities to enter tumor cells in laboratory studies, and to distribute to tissues within live mice as intended.

DNA nanoswitches open window on molecular interactions

Positioning two or more molecules along a long DNA strand can cause the DNA molecule to adopt different shapes if the molecules interact. Quickly and cheaply separating these shapes by a simple gel electrophoresis assay provides a wealth of information about how the molecules interact.

New scaffold for nanotechnology engineered from amyloid-like proteins

Design and computational simulation of amyloid proteins of diverse functions from diverse sources enable the self-assembly of proteins that could provide scaffolds for diverse applications.

Automated synthesis expands nanotechnology building block repertoire

Iterative coupling, purification, and cyclization of a large collection of organic building blocks promises a vast array of complex small and medium sized molecules as candidates for drug discovery, catalysis, and nanotechnology.

Targeted nanoparticles deliver molecules to resolve atherosclerotic inflammation

In tests in a mouse model of advanced atherosclerosis, core-shell nanoparticles, composed of block copolymers and targeted to sites of inflammation and vascular injury, delivered a bioactive peptide that improved key properties of advanced plaques.