Unrelated de novo enzyme replaces essential enzyme in cell

By |2018-02-05T07:07:29-08:00February 5th, 2018|Artificial Molecular Machines, Atomically Precise Manufacturing (APM), Bionanotechnology, Feynman Path, Molecular manufacturing, Molecular Nanotechnology, Nano, Nanobiotechnology, Nanodot, Nanotech, Nanotechnology, Productive Nanosystems, Research, Roadmaps, World-Shaping Technologies|

Iron-rich medium supports the growth of E. coli engineered to no longer have a natural Fes enzyme. They form small, unhealthy, red colonies because they accumulate iron bound to [...]

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Ultrafast DNA robotic arm: A step toward a nanofactory?

By |2018-01-25T12:37:45-08:00January 25th, 2018|Artificial Molecular Machines, Atomically Precise Manufacturing (APM), Bionanotechnology, Energy, Future Medicine, Molecular manufacturing, Molecular Nanotechnology, Nano, Nanobiotechnology, Nanodot, Nanomedicine, Nanotech, Nanotechnology, Research, World-Shaping Technologies|

Electric fields drive the rotating nano-crane – 100,000 times faster than previous methods. (Image: Enzo Kopperger / TUM) Rotation of the arm between two docking points (red [...]

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Design of hyperstable constrained peptides

By |2018-01-17T12:23:26-08:00January 17th, 2018|Atomically Precise Manufacturing (APM), Bionanotechnology, Computational nanotechnology, Foresight Kudos, Future Medicine, Molecular manufacturing, Molecular Nanotechnology, Nano, Nanobiotechnology, Nanodot, Nanomedicine, Nanotech, Nanotechnology, Productive Nanosystems, Research, World-Shaping Technologies|

Sixteen topologies of de novo designed hyperstable constrained peptides. Credit: Baker lab, University of Washington Protein design has been one of the major paths from current fabrication technology toward [...]

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From de novo protein design to molecular machine systems

By |2017-09-26T17:08:53-07:00January 30th, 2017|Artificial Molecular Machines, Atomically Precise Manufacturing (APM), Bionanotechnology, Computational nanotechnology, Foresight Kudos, Molecular manufacturing, Molecular Nanotechnology, Nano, Nanobiotechnology, Nanodot, Nanotech, Nanotechnology, Productive Nanosystems, Research, Reviews, Roadmaps|

A review from the group leading recent rapid progress in de novo protein design describes the successes, identifies the remaining challenges, and heralds the advance "from the Stone Age to the Iron Age" in protein design.

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Two-component, 120-subunit icosahedral cage extends protein nanotechnology

By |2017-09-26T16:37:11-07:00January 28th, 2017|Atomically Precise Manufacturing (APM), Bionanotechnology, Computational nanotechnology, Energy, Foresight Kudos, Future Medicine, Molecular manufacturing, Molecular Nanotechnology, Nano, Nanobiotechnology, Nanodot, Nanomedicine, Nanotech, Nanotechnology, Productive Nanosystems, Research|

Ten designs spanning three types of icosahedral architectures produce atomically precise multi-megadalton protein cages to deliver biological cargo or serve as scaffolds for organizing various molecular functions.

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Designing novel protein backbones through digital evolution

By |2017-09-28T12:13:14-07:00January 17th, 2017|Atomically Precise Manufacturing (APM), Bionanotechnology, Computational nanotechnology, Foresight Kudos, Molecular manufacturing, Molecular Nanotechnology, Nano, Nanobiotechnology, Nanodot, Nanotech, Nanotechnology, Research|

Computational recombination of small elements of structure from known protein structures generates a vast library of designs that balance protein stability with the potential for new functions and novel interactions.

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Adding modular hydrogen-bond networks to protein design

By |2017-09-28T12:21:15-07:00January 15th, 2017|Atomically Precise Manufacturing (APM), Bionanotechnology, Foresight Kudos, Foresight News, Foresight News Articles, Molecular manufacturing, Molecular Nanotechnology, Nano, Nanobiotechnology, Nanodot, Nanotech, Nanotechnology, Research|

Computer designed networks of hydrogen bonds allow programming specific interactions of protein interfaces, facilitating programming molecular recognition.

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Assembling a large, stable, icosahedral protein molecular cage

By |2017-09-28T12:39:51-07:00September 9th, 2016|Atomically Precise Manufacturing (APM), Bionanotechnology, Computational nanotechnology, Foresight Kudos, Molecular manufacturing, Molecular Nanotechnology, Nano, Nanobiotechnology, Nanodot, Nanotech, Nanotechnology|

A trimeric protein was designed to self assemble into a 60 unit icosahedron with a roomy interior that might find use to ferry molecular cargo into cells or as a chemical reactor.

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Rational improvement of DNA nanodevice function

By |2017-06-01T14:01:35-07:00August 13th, 2016|Artificial Molecular Machines, Atomically Precise Manufacturing (APM), Bionanotechnology, Computational nanotechnology, Molecular manufacturing, Molecular Nanotechnology, Nano, Nanobiotechnology, Nanodot, Nanotech, Nanotechnology, Research|

Recent research documents a structure-based rational design strategy combining molecular dynamics and single molecule imaging to improve the performance of a DNA tweezers that accurately positions an enzyme and its cofactor.

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Peptoid nanosheets assemble by different design rule

By |2017-06-01T14:01:36-07:00July 31st, 2016|Atomically Precise Manufacturing (APM), Bionanotechnology, Computational nanotechnology, Molecular manufacturing, Molecular Nanotechnology, Nano, Nanobiotechnology, Nanodot, Nanotech, Nanotechnology, Research|

Chains of monomers joined by non-biological peptoid bonds follow different rules of self-assembly and form structures not found in chains joined by the peptide bonds used to form proteins.

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