Bionanotechnology

From de novo protein design to molecular machine systems

By | 2017-06-01T14:01:34+00:00 January 30th, 2017|Artificial Molecular Machines, Atomically Precise Manufacturing (APM), Bionanotechnology, Computational nanotechnology, Foresight Kudos, Molecular manufacturing, Molecular Nanotechnology, Nano, Nanobiotechnology, Nanodot, Nanotech, Nanotechnology, Productive Nanosystems, Research, Reviews, Roadmaps|

A review from the group leading recent rapid progress in de novo protein design describes the successes, identifies the remaining challenges, and heralds the advance "from the Stone Age to the Iron Age" in protein design.

Two-component, 120-subunit icosahedral cage extends protein nanotechnology

By | 2017-06-01T14:01:34+00:00 January 28th, 2017|Atomically Precise Manufacturing (APM), Bionanotechnology, Computational nanotechnology, Energy, Foresight Kudos, Future Medicine, Molecular manufacturing, Molecular Nanotechnology, Nano, Nanobiotechnology, Nanodot, Nanomedicine, Nanotech, Nanotechnology, Productive Nanosystems, Research|

Ten designs spanning three types of icosahedral architectures produce atomically precise multi-megadalton protein cages to deliver biological cargo or serve as scaffolds for organizing various molecular functions.

Designing novel protein backbones through digital evolution

By | 2017-06-01T14:01:34+00:00 January 17th, 2017|Atomically Precise Manufacturing (APM), Bionanotechnology, Computational nanotechnology, Foresight Kudos, Molecular manufacturing, Molecular Nanotechnology, Nano, Nanobiotechnology, Nanodot, Nanotech, Nanotechnology, Research|

Computational recombination of small elements of structure from known protein structures generates a vast library of designs that balance protein stability with the potential for new functions and novel interactions.

Adding modular hydrogen-bond networks to protein design

By | 2017-06-01T21:34:12+00:00 January 15th, 2017|Atomically Precise Manufacturing (APM), Bionanotechnology, Foresight Kudos, Foresight News, Foresight News Articles, Molecular manufacturing, Molecular Nanotechnology, Nano, Nanobiotechnology, Nanodot, Nanotech, Nanotechnology, Research|

Computer designed networks of hydrogen bonds allow programming specific interactions of protein interfaces, facilitating programming molecular recognition.

Assembling a large, stable, icosahedral protein molecular cage

By | 2017-06-01T14:01:35+00:00 September 9th, 2016|Atomically Precise Manufacturing (APM), Bionanotechnology, Computational nanotechnology, Foresight Kudos, Molecular manufacturing, Molecular Nanotechnology, Nano, Nanobiotechnology, Nanodot, Nanotech, Nanotechnology|

A trimeric protein was designed to self assemble into a 60 unit icosahedron with a roomy interior that might find use to ferry molecular cargo into cells or as a chemical reactor.

Rational improvement of DNA nanodevice function

By | 2017-06-01T14:01:35+00:00 August 13th, 2016|Artificial Molecular Machines, Atomically Precise Manufacturing (APM), Bionanotechnology, Computational nanotechnology, Molecular manufacturing, Molecular Nanotechnology, Nano, Nanobiotechnology, Nanodot, Nanotech, Nanotechnology, Research|

Recent research documents a structure-based rational design strategy combining molecular dynamics and single molecule imaging to improve the performance of a DNA tweezers that accurately positions an enzyme and its cofactor.

Peptoid nanosheets assemble by different design rule

By | 2017-06-01T14:01:36+00:00 July 31st, 2016|Atomically Precise Manufacturing (APM), Bionanotechnology, Computational nanotechnology, Molecular manufacturing, Molecular Nanotechnology, Nano, Nanobiotechnology, Nanodot, Nanotech, Nanotechnology, Research|

Chains of monomers joined by non-biological peptoid bonds follow different rules of self-assembly and form structures not found in chains joined by the peptide bonds used to form proteins.

Engineered protein assembles molecules into atomically precise lattice

By | 2017-06-01T14:01:36+00:00 July 30th, 2016|Atomically Precise Manufacturing (APM), Bionanotechnology, Computational nanotechnology, Molecular manufacturing, Molecular Nanotechnology, Nano, Nanobiotechnology, Nanodot, Nanotech, Nanotechnology, Research|

An engineered protein controls the assembly of C60 fullerene molecules into an atomically precise lattice that conducts electricity while neither component alone would.

Protein design provides a novel metabolic path for carbon fixation

By | 2017-06-01T14:01:36+00:00 June 8th, 2016|Atomically Precise Manufacturing (APM), Bionanotechnology, Computational nanotechnology, Energy, Molecular manufacturing, Molecular Nanotechnology, Nano, Nanobiotechnology, Nanodot, Nanotech, Nanotechnology, Productive Nanosystems, Research|

Computational design of an enzyme that carboligates three one-carbon molecules to form one three-carbon molecule, an activity that does not exist in nature, provides proof-of-principle for a novel metabolic pathway for carbon fixation.

Triple helices stabilize macroscopic crystals for DNA nanotechnology

By | 2017-06-01T14:01:37+00:00 May 5th, 2016|Atomically Precise Manufacturing (APM), Bionanotechnology, Molecular manufacturing, Molecular Nanotechnology, Nano, Nanobiotechnology, Nanodot, Nanotech, Nanotechnology, Productive Nanosystems, Research|

A DNA strand capable of forming a triple helix with a portion of the DNA double helices in a macroscopic DNA crystal enhances the weak interactions holding the crystal together so that the crystal remains stable in the absence of a high ionic strength environment.